Postdoc position in pediatric neurooncology research (m/f/d) (KHS-43055)
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Description
We are seeking a talented and driven Postdoctoral Researcher to investigate the biological mechanisms driving pediatric low-grade glioma (pLGG) regrowth following MAPK inhibitor (MAPKi) withdrawal. This project will explore how changes in MAPK pathway activity and microglia recruitment contribute to tumor recurrence, using a combination of molecular biology, cell culture, and microenvironment-focused assays. The findings aim to inform improved treatment strategies and prevent relapse in young patients.
Primary Duties & Responsibilities:
- develop and utilize in vitro and ex vivo models to study pLGG regrowth after MAPKi withdrawal. Assess MAPK pathway reactivation and downstream effects on tumor cell biology
- investigate microglia recruitment and its contribution to tumor recurrence using co-culture systems and functional assays
- integrate experimental results with bioinformatics workflows for comprehensive analysis
- publish in high-impact international journals and present at major scientific conferences
- supervise and mentor PhD, MD, MSc, and BSc students within the project
Required Skills & Qualifications:
- PhD in molecular biology, neurobiology, immunology, cancer biology, or related field
- expertise in molecular and cellular biology methods (e.g., real-time PCR, Western blotting, immunostaining, microscopy)
- experience in tumormicroenvironment studies, particularly microglia or immune cell biology, is desirable
- familiarity with MAPK signaling or targeted therapy research is a plus
- skills in bioinformatics (R, Python) are advantageous
- experience with BSL-2 laboratory work preferred
- experience with the scientific publication process necessary
- excellent English communication skills, written and spoken
- highly motivated, independent, and team-oriented
We offer you even more:
- a stimulating research environment with a strong focus on translational pediatric neuro-oncology
- the opportunity to explore tumormicroenvironment interactions in clinically relevant models
- access to advanced cell culture systems, imaging platforms
- support for career development, including teaching and habilitation opportunities
- offer networking opportunities in national and international pediatric brain tumor research networks (e.g. Everest, Itcc, SIOPE BTG, PLGA coalition)
- Classification is based on TV-L in pay grade E13 if the personal and collective agreement requirements are met.
Reference number:170/2026
* Limited to 24 months, with option to extend
Regardless of origin, age, gender or disability - you are welcome here at Jena University Hospital.
Anschrift für Bewerbungen
03641/ 9-33203
03641/ 9-33206
bewerbung@med.uni-jena.de
http://www.uniklinikum-jena.deUniversitätsklinikum Jena
Geschäftsbereich Personalmanagement
Bachstraße 18
07740 Jena
