PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research (KHS-42629)
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Description
New Perspectives in CNG Channel Research: Mechanistic Insights and Emerging Therapeutic Strategies for Retinal Degeneration
PhD Position (m/f/d) in Ion Channel Physiology and Retinal Research
This project centers on cyclic nucleotide-gated (CNG) channels in retinal photoreceptors. These channels are essential for visual signal transduction and play a pivotal role in disorders such as retinitis pigmentosa (RP) and achromatopsia (ACHM). The aim is to develop selective pharmacological strategies targeting rod- and cone-specific CNG channel isoforms and to elucidate the underlying molecular mechanisms. The PhD position is funded through a PRO RETINA Foundation fellowship.
Application:
Please submit your application documents (cover letter, CV, certificates, list of publications and a one-page summary of previous scientific work) in electronic form.Your Responsibilities:
- Perform electrophysiological recordings (e.g., patch-clamp) on heterologously expressed channels in Xenopus oocytes; analyze novel cGMP analogs and allosteric modulators
- Investigate ligand binding to retinal CNG channels to clarify the mechanisms driving isoform-specific channel activation and regulation
- Integrate experimental findings with computational approaches (molecular docking, molecular dynamics simulations); conduct systematic analysis and interpretation of electrophysiological and molecular data
- Prepare manuscripts and present results at scientific conferences
Your Profile:
- Masters degree in Biology, Biochemistry, Pharmacy, Biophysics, or a related discipline
- Preferably initial experience with electrophysiological techniques (e.g., patch-clamp), cell/molecular biology methods, or molecular docking and MD simulations
- Basic knowledge of ion channel physiology is an advantage
- Highly motivated, well-organized, and curious mindset
- Strong communication and teamwork skills
- Excellent written and spoken English skills; good working knowledge of German is an advantage
- Solid computer skills
- Willingness to travel for project-related meetings and conferences
We Offer:
- An innovative doctoral project in translational retinal research
- Modern laboratory facilities and an academically stimulating environment
- Intensive scientific supervision and opportunities for publication
- PRO RETINA Foundation PhD fellowship
Application:
Please submit your application documents (cover letter, CV, certificates, list of publications and a one-page summary of previous scientific work) in electronic form.
Funding is provided through a doctoral fellowship from the PRO RETINA Foundation. It is expressly noted that no contract of employment but rather a visiting scholar agreement will be signed with the institution issuing the fellowship. A letter of acceptance for the doctoral fellowship will be signed directly between the PRO RETINA Foundation and the successful applicant.
Reference number: 130/2026
* Fixed-term contract for 2 years, with the option to extend
** Scholarship of 1,500 euros
We appreciate your valuable contribution and look forward to getting to know you!
Regardless of origin, age, gender or disability - you are welcome here at Jena University Hospital.
Anschrift für Bewerbungen
03641/ 9-33203
03641/ 9-33206
bewerbung@med.uni-jena.de
http://www.uniklinikum-jena.deUniversitätsklinikum Jena
Geschäftsbereich Personalmanagement
Bachstraße 18
07740 Jena
