Postdoc in Cancer Research (m/w/d) (KHS-24977)
Multiple myeloma is a cancer that causes massive destruction of the extracellular matrix in bone, and isconsequently one of the most serious bone diseases. Damage is induced following extensive osteolytic activity ofosteoclasts while blocking bone regeneration. The project focuses on detection of damage to the extracellularmatrix and microstructure at the initial disease stage seeking new molecular and ultrastructural biomarkers forbone extracellular matrix, employing advanced materials-science methods for microstructure imaging. We willquantify in space and time, early extracellular damage evolution at local sites after MM cell inoculation andthroughout the skeleton as the MM cells spread. Using transcriptomic profiling, we will track the components ofour candidate pathway and its molecular targets to identify yet unknown very early molecular changes inosteocyte gene expression and pathway activity. This will allow us to identify new biomarkers and innovativetherapeutic targets in host and tumor.
• Development of project: develop the model, perform experiments, evaluate and quantify resultsensuring the project evolves and fulfills the goals and work packages.
• Produce written reports and draft papers.
• Present your results at local meetings and national and international conferences.
• Assist with training other researchers, including Masters’ and undergraduate project students.
• Contribute to enhancing a welcoming sustainable and collaborative environment within the group.
• A PhD in Life Sciences (e.g. Biology, Biochemistry, Veterinary Medicine) or related
• Experience with conditional knockout or transgenic mice and handling of animals
• Experimental background in one or more of the following subjects is beneficial: Molecular
Biology, CellBiology, Biochemistry.
• Highly motivated individuals with an interest in joining one of the interdisciplinary
research areas of thePriority Programme (SPP 2084)
• The ability to work creatively and independently towards developing your own research
• English communication skills, both written and spoken
• A highly communicative atmosphere within an energetic scientific network
• Cutting-edge research in an international team
• A comprehensive mentoring program and soft skill courses for early career researchers at
the GraduateSchool of Life Sciences at the University of Würzburg
• Würzburg with the UNESCO World Cultural Heritage Site Residence Palace
• A family-friendly working environment with a variety of offers for families
• A wide range of university sports activities
The three year full-time doctoral researcher position (100% TV-L) will be funded through the GermanResearch Foundation (DFG). To promote gender equality in science, applications by female candidates areespecially welcome. Candidates with severe disabilities will be given preference in the case of equal qualificationsand suitability.
Applications in English should comprise a letter of motivation with a description of scientific achievements andacademic goals (2 pages), your CV, abstract of Bachelor / Master /doctoral thesis, contact information of twoacademic references, copies of academic certificates. Please submit your application via email (email@example.com)to Prof. Franziska Jundt by 10 September 2022:
Ziouti F*, Rummler M*, Steyn B, Thiele T, Seliger A, Duda GN, Bogen B, Willie BM*, Jundt F*, Prevention of BoneDestruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 inMyeloma Bone Disease. International Journal of Molecular Sciences, 2021, 22:3840. *contributed equallyRummler M*, Ziouti F*, Bouchard AL, Brandl A, Duda GN, Bogen B, Beilhack A, Lynch ME, Jundt F*, Willie BM*,Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model ofmyeloma bone disease. Acta Biomaterialia, 2021, 119:247-258. *contributed equallyZiouti F, Soares AP, Moreno-Jiménez I, Rack A, Bogen B, Cipitria A, Zaslansky P, Jundt F, An Early MyelomaBone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the ExtracellularMatrix, 2020, J Oncol. 2020:3985315.
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