PhD-students (Doktoranden) in CAR-T cell engineering for cancer therapy (m/w/d) (KHS-25909)
The project covers engineering of tumor-specific T cells through genetic modification with synthetic CARs, and analysis of their anti-tumor function in vitro and in in vivo models. In this project, you will focus on the refinement of relevant bone marrow organoids to improve (personalized) preclinical investigation of CAR-T cell functionality in hematologic malignancies and evaluate relevant resistance mechanisms. Mechanistic insights will inform the construction of a next generation of CAR-T cells with improved anti-tumor function. The close cooperation with our clinical partners guarantees the immediate translational relevance of the project.
You will be able to explore new concepts in receptor design and investigate novel approaches to improve T cell functionality. You will be able to work on an independent, high-impact project designed for a 3-year period. Projects can start immediately (from Oct 2022). Salary is paid according to the German public service scale based on candidates' background and experience (TV-L).
Applicants for this position should have or be about to obtain their master’s degree in biomedicine, biology, biochemistry, or a related field with excellent result. They should have experience in (T cell) immunology and molecular biology, hands-on expertise in multi-color flow cytometric analysis and experience in data analysis using different software applications (FlowJo, Graph Pad Prism). Key characteristics of successful applicants will include a high level of enthusiasm, result-oriented work style, analytical thinking, excellent communication and
time management skills and the ability to face scientific challenges with creativity and dedication.
Our labs provide a stimulating environment with an international team of experienced, innovative scientists, medical doctors, and technicians with numerous national and international collaborators. The Division of Medicine II/ Department of Hematology at the University of Würzburg (Chair: Prof. H. Einsele) runs one of the largest bone marrow transplantation and cell therapy programs in Germany providing numerous opportunities for bench to bedside interaction, education, and clinical translation. You will be able to enroll in a structured PhD program through the Würzburg Graduate School of Life Sciences and be supported by a thesis committee of 3-4 experienced scientists.
Please send your application including a letter of motivation (German or English), expected availability date, CV and list of publications, and an expressive letter of reference or the names of two potential referees as a combined pdf-file by email to:
firstname.lastname@example.org, Reference: “PhD-Student”Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik II – Hämatologie/Onkologie, Dr. Sophia DanhofVersbacher Straße 5, Building E4/R 3.07, 97078 Würzburg, Germany
Anschrift für Bewerbungen